Introducing Tailored Covalency

Traditional oral small molecule drugs are convenient, but often have side effects because they may not be selective.

Injectable antibody drugs are highly specific therapies, but an injection is not convenient for the patient.

What if you could have the best of both worlds?

Principia’s novel approach to drug development combines the dosing convenience of a small molecule drug with characteristics of an antibody. Our drugs are designed to be effective, potent, selective, durable and safer than traditional small molecule drugs.

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A pipeline of differentiated drug candidates that may offer superior safety and efficacy

Autoimmune / Inflammatory Diseases

Phase 1
PRN1008: BTK Inhibitor / Rheumatoid Arthritis
PRN1008: BTK Inhibitor / Undisclosed Orphan Indication
IL-17 Pathway Inhibitor: Autoimmune / Inflammatory
Undisclosed: Autoimmune / Inflammatory


PRN1371: FGFR Inhibitor / Multiple Cancers
BTK Inhibitor: Hematologic Malignancies