About Principia

Developing Transformational Medicines

Principia Biopharma Inc., a private, clinical-stage biopharmaceutical company, has generated a pipeline of clinical and preclinical stage molecules for autoimmune/inflammatory diseases and oncology. By utilizing its proprietary Tailored Covalency® technology, the company is revolutionizing the design of oral small molecule therapies for more potent, selective, durable drugs with the goal to enhance the risk benefit profile compared to existing therapies. PRN1008, a reversible covalent BTK inhibitor, is being evaluated in a Phase 2 trial for pemphigus vulgaris, an orphan autoimmune disease. PRN1371, a potent, selective FGFR inhibitor is in a Phase 1 trial for solid tumors. PRN2246, a very potent BTK inhibitor that is able to cross the blood-brain barrier, is completing IND enabling studies. A series of highly selective orally bioavailable immunoproteasome inhibitors round out the company’s portfolio.

Powered by Tailored Covalency®

Principia Biopharma challenges traditional drug discovery by utilizing its proprietary technology to discover new medicines that combine the dosing convenience of an oral small molecule drug with the specificity of an antibody.

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Our Leadership

Principia’s leadership team includes biotechnology executives and veteran drug developers who are passionate about creating a new way to develop better small molecule drugs.


Board of Directors