Our leadership team has an unwavering commitment to helping patients with serious immune-mediated diseases.

We are led by an experienced leadership team with a proven track record in the biopharmaceutical industry. Collectively, our leadership team has contributed to drug discovery and development as well as approval, launch and commercialization of multiple innovative, blockbuster medicines.
David Goldstein, Ph.D.

David Goldstein, Ph.D.


"Transforming drug discovery for the treatment of immune-mediated diseases."

Dr. Goldstein has served as Site Head since 2020 and Chief Scientific Officer since 2016. He is a named inventor of 43 patents, the author of more than 40 scientific publications, and a recognized expert in drug discovery for autoimmune diseases and cancer. Prior to his current role, Dr. Goldstein was the Senior Vice President and Head of Drug Discovery. This role included the crafting of the scientific and business strategy for the company’s launch in 2011. Prior to joining Principia, from 1994 to 2011, Dr. Goldstein held positions of increasing responsibility at Roche including Senior Director, Medicinal Chemistry and Head of Inflammation Chemistry.

Dr. Goldstein received a B.A. in Chemistry from Franklin and Marshall College and a Ph.D. in Chemistry from the University of Virginia.

Betsy Santos

Betsy Santos


"Culture whisperer."

Ms. Santos has served as Principia’s Senior Vice President of People since 2014 and leads training, development, culture, employee relations, performance management, and benefits. From 2007 to 2014, Ms. Santos held increasingly responsible positions at Switchfly (a SaaS platform for the travel and loyalty industries), most recently as Vice President of Human Resources. From 1998 to 2007, Ms. Santos’ previous experience included various Human Resources roles at CV Therapeutics, Cepheid and Genentech.

Ms. Santos received a B.A. in Sociology from the University of California, Davis.