Patients

Pemphigus Phase 3 graphic

Principia Biopharma is dedicated to bringing transformative oral therapies to patients with significant unmet medical needs to improve patient outcomes and experience. Our proprietary Tailored Covalency® platform enables us to design and develop oral therapies that we believe will rival the effectiveness and safety of injectable biologics, yet maintain the convenience of a pill.

We are currently enrolling patients in the following clinical trials:

Pemphigus (Pemphigus Vulgaris and Pemphigus Foliaceus)

Phase 2 clinical trial with PRN1008 for pemphigus vulgaris, an autoimmune blistering skin disorder that has limited options for treatment. Clinical trial information can be found here (https://www.clinicaltrials.gov/ct2/show/NCT02704429) and information related to the disease can be found here (http://www.pemphigus.org/).

Immune Thrombocytopenic Purpura

Phase 1/2 clinical trial with oral PRN1008 for Immune Thrombocytopenic Purpura (ITP), an autoimmune disease causing low platelet levels in the blood.  Clinical trial information can be found here (https://clinicaltrials.gov/ct2/show/NCT03395210) and information related to the disease can be found here (https://pdsa.org/).

Solid Tumors (Including Bladder Cancer)

Phase 1 expansion and safety study with PRN1371, a selective, oral, FGFR 1-4 inhibitor in patients with solid tumors. Clinical trial information can be found here (https://www.clinicaltrials.gov/ct2/show/NCT02608125).

Please check back again for updates on future clinical trials.